How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
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EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick
Manage episode 393540661 series 2631947
Contenu fourni par Sano Genetics. Tout le contenu du podcast, y compris les épisodes, les graphiques et les descriptions de podcast, est téléchargé et fourni directement par Sano Genetics ou son partenaire de plateforme de podcast. Si vous pensez que quelqu'un utilise votre œuvre protégée sans votre autorisation, vous pouvez suivre le processus décrit ici https://fr.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
179 episodes
Partager
Manage episode 393540661 series 2631947
Contenu fourni par Sano Genetics. Tout le contenu du podcast, y compris les épisodes, les graphiques et les descriptions de podcast, est téléchargé et fourni directement par Sano Genetics ou son partenaire de plateforme de podcast. Si vous pensez que quelqu'un utilise votre œuvre protégée sans votre autorisation, vous pouvez suivre le processus décrit ici https://fr.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
179 episodes
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Similaire à The Genetics Podcast
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
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continue reading
How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
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continue reading
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continue reading
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continue reading
Artificial Intelligence has suddenly gone from the fringes of science to being everywhere. So how did we get here? And where's this all heading? In this new series of Science Friction, we're finding out.
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continue reading
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Mettez-vous hors ligne avec l'application Player FM !
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