01_06 Metastatic Gastroesophageal Cancer

Talking About Tumors with Ryann and Ryan - A medical oncology podcast

1. Principles of management

2. Key chemotherapy tegimens

3. Immunotherapy/HER-2 Directed Approach

4. Alpha spending, hierarchical statistical design

5. Later line approach and bottom lines to approach

Citations

As always, citations, and sources include education from our respective training programs, the Devita textbook, and Uptodate.com

DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015.

Uptodate.com Waltham, MA: Wolters Kluwer.

Some highlighted references recommended to read related to this specific episode:

1. Veer E ter et al. J Natl Cancer Inst. 2016;108(10). doi:10.1093/JNCI/DJW166

2. Guimbaud R et al. J Clin Oncol. 2014;32(31):3520-3526. doi:10.1200/JCO.2013.54.1011

3. Cunningham D et al. NEJM. 2008;358(1):36-46. DOI: 10.1056/NEJMoa073149

4. Wagner AD et al. J Clin Oncol. 2006;24(18):2903-2909. doi:10.1200/JCO.2005.05.0245

5. Janjigian YY et al. Lancet Oncol. 2020;21(6):821-831. doi:10.1016/S1470-2045(20)30169-8

6. ter Veer et al. Int J Cancer. 2018;143(2):438-448. doi:10.1002/IJC.31325

7. Doki Y et al. NEJM. 2022;386(5):449-462. doi: 10.1056/NEJMoa2111380.

8. Shitara K et al. NEJM. 2020;382(25):2419-2430. DOI: 10.1056/NEJMoa2004413

9. Wilke H et al. The Lancet Oncology. 2014;15(11):1224-1235. doi:10.1016/S1470-2045(14)70420-6

10. Chao J et al. JAMA Oncol. 2021;7(6):895-902. doi:10.1001/JAMAONCOL.2021.0275

11. Janjigian YY et al. Lancet. 2021;398(10294):27-40. doi:10.1016/S0140-6736(21)00797-2

12. Shitara K et al. Nature. 2022;603:7903. doi:10.1038/s41586-022-04508-4

13. Sun JM et al. The Lancet. 2021;398(10302):759-771. doi:10.1016/S0140-6736(21)01234-4

14. Shitara K, et al. JAMA Oncology. 2020;6(10):1571-1580. doi:10.1001/JAMAONCOL.2020.3370

15. Bang YJ et al. Lancet. 2010;376(9742):687-697. doi:10.1016/S0140-6736(10)61121-X

Disclosures

Talking about Tumors with Ryan and Ryann is not medical advice. We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose. All opinions are those of whoever stated them. We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic.