Calorie Restriction & Fasting: Aging, Immunity, Health Biomarkers, Stress, Genetics | Gary Churchill | #183

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About the guest: Gary Churchill, PhD is a statistician & geneticist at the Jackson Research laboratory in Maine. His lab uses a systems approach to investigate the genetics of complex biological traits in health & disease.

Episode summary: Nick and Dr. Churchill discuss: his recent papers looking at the effects of caloric restriction & intermittent fasting on nearly 1,000 genetically diverse mice; how dietary restrictions affect longevity, metabolic health, immunity, and hundreds of biomarkers; the role of genetics vs. diet in aging; and more.

Related episodes:

• M&M #139: Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease

*This content is never meant to serve as medical advice.
*Full episode available free on Substack & YouTube.
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Chapitres

1. Calorie Restriction & Fasting: Aging, Immunity, Health Biomarkers, Stress, Genetics | Gary Churchill | #183 (00:00:00)

2. Overview of the Jackson Lab (00:03:38)

3. Dietary Restriction and Study Design (00:11:14)

4. New Study: Results & Findings (00:34:56)

5. Analysis of Health & Metabolic Traits (00:43:39)

6. Genetic Factors & Lifespan (00:47:55)

7. Immune System & Stress Resilience (01:03:52)

8. Social Factors and Frailty (01:10:40)

9. Conclusions & Future Directions (01:13:23)