New Hope For a new modified CAR T Therapy For Multiple Myeloma and other fatal hematologic malignancies

Facing the Cancer Revolution

In this episode of Facing the Cancer Revolution Podcast we discuss Multiple myeloma cancer and new CAR-T Treatments for bone marrow cancers.

Multiple myeloma is a type of blood cancer that affects plasma cells, which are a type of white blood cells that produce antibodies to help fight infections. Treatment options for multiple myeloma have improved significantly in recent years with the introduction of new drugs and therapies.

• Immunomodulatory Drugs (IMiDs): boost the immune system and target cancer cells. .
• Proteasome inhibitors: Proteasomes are enzymes that break down proteins in cells, including those that cause cancer cells to grow.
• Monoclonal antibodies: These are drugs that target specific proteins on the surface of cancer cells. .
• CAR T-cell therapy: This is a type of immunotherapy where T cells (a type of immune cell) are modified in a laboratory to produce chimeric antigen receptors (CARs) that recognize and attack cancer cells.
• High-dose chemotherapy and stem cell transplant: This treatment involves high-dose chemotherapy to kill cancer cells followed by a stem cell transplant to replace the damaged cells.
• Targeted therapy: This is a type of treatment that targets specific molecules or genes that are involved in the growth and survival of cancer cells. .

Resources Discussed in Podcast

https://www.dana-farber.org/cellular-therapies-program/car-t-cell-therapy/car-t-cell-therapy-for-multiple-myeloma/

https://www.mayoclinic.org/diseases-conditions/multiple-myeloma/symptoms-causes/syc-20353378

https://stemcellthailand.org/oncology/multiple-myeloma-treatment/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439649/

https://www.mdanderson.org/cancerwise/car-t-cell-therapy-puts-smoldering-and-multiple-myeloma-survivor-in-remission.h00-159543690.html

Links to Previous Shows

1. Cancer immunotherapy: from T cell basics
2. Next generation of cancer treatments
3. Advanced liver cancer
4. Management of Liver Cancer
5. Biomarker-driven therapies for lung cancer
6. Understanding Carcinogenesis
7. Prostate Cancer
8. Pancreatic Cancer