BLA 106: GLP-1s for weight loss, and Physical Activity and Cardiometabolic Health

Building Lifelong Athletes

In today's podcast we talk about whether GLP-1 agonists like Semaglutide can be helpful for osteoarthritis, and we look at the true link between physical activity and cardiometabolic health.

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CHAPTERS:
00:00 - Intro
00:15 - Article 1: GLP-1 for Knee Osteoarthritis
00:51 - Overview
01:56 - Design
02:59 - Weight Loss Results
03:59 - Pain Reduction Results
05:02 - Safety
06:20 - Mechanism of Action
07:15 - Takeaways
10:00 - Article 2: PA, CRF, and metabolic health
10:11 - Background
11:37 - Previous Research
12:56 - Study Design
15:04 - Marker 19
19:26 - Importance of Exercise Intensity
20:20 - Strengths and Limitations
21:12 - Clinical Implications
21:60 - Outro
References:

Bliddal, H., Bays, H., Czernichow, S., Hemmingsson, J. U., Hjelmesæth, J., Morville, T. H., Koroleva, A., Neergaard, J. S., Sánchez, P. V., Wharton, S., Wizert, A., & Kristensen, L. E. (2024). Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. New England Journal of Medicine, 391(17), 1573–1583. https://doi.org/10.1056/NEJMoa2403664 Fridolfsson, J., Ekblom-Bak, E., Ekblom, Ö., Bergström, G., Arvidsson, D., & Börjesson, M. (2024). Fitness-related physical activity intensity explains most of the association between accelerometer data and cardiometabolic health in persons 50–64 years old. British Journal of Sports Medicine, 58(21), 1244–1250. https://doi.org/10.1136/bjsports-2023-107451

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.