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Episode 28. Management of CCUS
Manage episode 374605215 series 3369804
Contenu fourni par Rajshekhar Chakraborty and Ashwin Kishtagari, Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff. Tout le contenu du podcast, y compris les épisodes, les graphiques et les descriptions de podcast, est téléchargé et fourni directement par Rajshekhar Chakraborty and Ashwin Kishtagari, Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff ou son partenaire de plateforme de podcast. Si vous pensez que quelqu'un utilise votre œuvre protégée sans votre autorisation, vous pouvez suivre le processus décrit ici https://fr.player.fm/legal.
In this episode, we discuss the diagnosis and management/monitoring of Clonal Cytopenias of Unknown Significance (CCUS) with Dr. Uma Borate. We also discuss the emerging data on risk stratification and key trials in this space that are currently ongoing. Here are the shownotes:
1. CCUS and risk of transformation to myeloid neoplasms:
https://www.sciencedirect.com/science/article/pii/S0006497121013471
2. Prediction of risk for myeloid neoplasms in clonal hematopoiesis:
https://evidence.nejm.org/doi/full/10.1056/EVIDoa2200310
3. CHRS risk score:
4. Germline predisposition to clonal hematopoiesis:
https://www.sciencedirect.com/science/article/abs/pii/S0145212623006094?via%3Dihub
https://www.nature.com/articles/s41586-020-2819-2
5. Cancer therapy shapes the fitness landscape of clonal hematopoiesis:
https://www.nature.com/articles/s41588-020-00710-0
6. Canakinumab for the prevention of progression to cancer in patients with Clonal Cytopenias of Unknown Significance, IMPACT Study:
7. Ivosidenib in patients with CCUS and mutations in IDH1:
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