Will Isotonitazene Be Our New Overdose Crisis Drug?

Anesthesiology News Presents

The Drug Enforcement Administration Washington Division is warning local residents of a dangerous new drug emerging in the D.C. area that is as deadly as fentanyl. We as neurocritical care practitioners may therefore soon find ourselves caring for patients that have overdosed on this drug and may be suffering from severe hypoxic injury and coma.

In the fall of 2019, a new synthetic opioid named isotonitazene made its debut in the U.S. and Canada. The drug, which is not a derivative of fentanyl but is equally as potent, is legal to export from China and was not initially banned in North America or Europe despite not being an approved pharmaceutical product anywhere in the world. However, the DEA has now issued an emergency temporary order placing isotonitazene as a Schedule I drug.

Isotonitazene is a derivative of benzimidazole, an opioid analgesic. It is 500 times more potent than morphine and has slightly more potency than fentanyl with respect to causing relaxation, euphoria and respiratory depression. In March 2020, isotonitazene was found in counterfeit hydromorphone tablets sold on the streets of the United States and Canada. There are also reports that this is being mixed with other street drugs such as cocaine. Isotonitazene is a growing public health risk and a real danger to those who misuse drugs, especially users of heroin and cocaine. Street names of this drug including nitazene or ISO may be volunteered by patients and other involved parties.

Another major issue for us in the ER and neuro ICU may be that normal toxicology screens do not identify this drug. Luckily, however, the drug is responsive to naloxone. It may be important for us to collect blood samples from patients responsive to naloxone but who tested negative for narcotics in our facilities and send it for analysis to help government agencies track the distribution of this drug. I also suggest that blood samples be sent for patients who present with hypoxic brain injury with unclear causes, especially individuals at risk.