330 - Vascular Changes in Alzheimer's Disease: January 2023

AMiNDR: A Month in Neurodegenerative Disease Research

Elyn's back with more insight from the field on how blood vessel health impacts brain health. Tune in for a journey through mechanisms underlying increased risk from "vascular risk factors" like hypertension, diabetes, and atrial fibrillation, lots of neuroimaging studies providing clinical insights, and several interesting novel therapeutic avenues. If you weren't already convinced that the vasculature is relevant in the context of AD, you sure will be after this episode!

Sections in this episode:

Cerebral blood flow and hypoperfusion (4:08)

More clinical insights (10:53)

Blood-brain barrier and amyloid-endothelial cell interactions (19:52)

Therapeutic avenues targeting the vasculature (27:12)

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To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:

https://drive.google.com/file/d/1jxLnkb02ovKVtHq_MNwg738QyyYWmA4y/view

To access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:

https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharing

You can also find all of our bibliographies on our website: amindr.com.

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We at AMiNDR are eager to hear from you! We opened up a survey available until the end of April for you to tell us what we are doing well, and where we can improve. Access the survey at tinyurl.com/amindrsurvey. All survey responses will be anonymous. By doing the survey, you can choose to enter a draw for a $15USD gift card for any location you choose!

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Follow-up on social media for more updates!

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Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don’t forget to subscribe to hear about new episodes as they come out too.

Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/.

Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Elyn Rowe, edited by Isabelle Vaux, and reviewed by Cassi Friday and Anusha Kamesh. The bibliography was made by Anjana Rajendran and wordcloud was created by Lara Onbasi (www.wordart.com).

Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer’s Disease papers into episodes each month. For January 2023, the sorters were Elyn Rowe, Christy Yu, Eden Dubchak, Ben Cornish, Kevin Nishimura, Anelya Gandy, Salodin Al-Achkar, and Rob Cloke. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, Lara Onbasi, Joseph Liang, and Judy Cheng, for keeping everything running smoothly.

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.

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*About AMiNDR: *

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"