A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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EP 155: Adeno-associated virus as a delivery vector for genetic eye disease treatment, with Paul Wille of Abeona Therapeutics
MP3•Maison d'episode
Manage episode 444521785 series 2631947
Contenu fourni par Sano Genetics. Tout le contenu du podcast, y compris les épisodes, les graphiques et les descriptions de podcast, est téléchargé et fourni directement par Sano Genetics ou son partenaire de plateforme de podcast. Si vous pensez que quelqu'un utilise votre œuvre protégée sans votre autorisation, vous pouvez suivre le processus décrit ici https://fr.player.fm/legal.
1:30 Intro to The Genetics Podcast
2:20 Welcome to Paul
2:53 Adeno-associated virus (AAV) biology and its advantages over other viral vectors
5:20 The gene therapy landscape and options for therapy development and delivery
6:49 The limitations of working with AAV to deliver gene therapy, including genome capacity and challenges with dividing cells
9:37 Why enormous bioreactors and huge volumes are necessary in the AAV manufacturing process
11:22 Why the eye is an ideal target for AAV gene therapy, and the potential of single-dose gene therapies
13:36 Advantages of AAVs in delivering therapies into multiple different cell types
15:17 Moving pre-clinical AAV delivered therapies into a clinical setting
17:52 How Abeona’s therapies aim to address different types of inheritance patterns
18:53 The current landscape of monogenic eye disease and Abeona’s approach to inherited eye conditions
21:38 Exploring current relationships between government, industry, and academia when supporting research for rare diseases
22:27 Paul’s transition from academia to industry
26:12 How the barrier between academia and industry is becoming more porous and bidirectional – and what that means for research
28:06 Paul’s enthusiasm for a cutting-edge area of precision medicine that has yet to gain mainstream attention
30:38 Closing remarks
184 episodes
MP3•Maison d'episode
Manage episode 444521785 series 2631947
Contenu fourni par Sano Genetics. Tout le contenu du podcast, y compris les épisodes, les graphiques et les descriptions de podcast, est téléchargé et fourni directement par Sano Genetics ou son partenaire de plateforme de podcast. Si vous pensez que quelqu'un utilise votre œuvre protégée sans votre autorisation, vous pouvez suivre le processus décrit ici https://fr.player.fm/legal.
1:30 Intro to The Genetics Podcast
2:20 Welcome to Paul
2:53 Adeno-associated virus (AAV) biology and its advantages over other viral vectors
5:20 The gene therapy landscape and options for therapy development and delivery
6:49 The limitations of working with AAV to deliver gene therapy, including genome capacity and challenges with dividing cells
9:37 Why enormous bioreactors and huge volumes are necessary in the AAV manufacturing process
11:22 Why the eye is an ideal target for AAV gene therapy, and the potential of single-dose gene therapies
13:36 Advantages of AAVs in delivering therapies into multiple different cell types
15:17 Moving pre-clinical AAV delivered therapies into a clinical setting
17:52 How Abeona’s therapies aim to address different types of inheritance patterns
18:53 The current landscape of monogenic eye disease and Abeona’s approach to inherited eye conditions
21:38 Exploring current relationships between government, industry, and academia when supporting research for rare diseases
22:27 Paul’s transition from academia to industry
26:12 How the barrier between academia and industry is becoming more porous and bidirectional – and what that means for research
28:06 Paul’s enthusiasm for a cutting-edge area of precision medicine that has yet to gain mainstream attention
30:38 Closing remarks
184 episodes
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