Episode 23: Tanycyting: Characterising a neural stem cell niche in the hypothalamus

Preprints in Motion

This week we discuss a population of stem cells called tanycytes which line hypothalamus in the brain with Alex Moore (@alexthemessiah) an Operational Research Analyst in the Civil Service & Kavitha Chinnaiya a Post Doc from the University of Sheffield (@sheffielduni). Tanycytes are population of cells which line the 3rd ventricle in the hypothalamus, self renew and give rise to neurons and glia within the brain. We speak to them about the key findings of their paper which includes expanding on their roles as stem cells, as well as further characterising them with a variety of markers including NrCAM. To do this they evoked a range of techniques including the use of spheroids and single cell RNA sequencing and we chatted to them about those. We also find out about working in the Civil Service and all the skills that PhD offers that helped with this move from academia.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.12.15.472761v1.full

This episode was hosted by Jonny Coats, produced by Emma Wilson and edited by John D Howard .

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Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).