BC 007 – Efficacité cardiovasculaire de l’évolocumab chez les sujets avec dyslipidémie (étude FOURIER)

BaladoCritique - club de lecture médical

Dans cette septième baladodiffusion, les Drs Luc Lanthier et Danielle Pilon discutent de l’effet de l’évolocumab, un inhibiteur des PCSK9 sur les événements cardiovasculaires, en plus de réviser la littérature médicale de février et mars 2017.

Quiz clinique (1 min 49), étude principale (2 min 38), critique (19 min 34), autres articles (28 min 50), réponse au quiz clinique (33 min 50)

Référence principale

Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, et al. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017. PubMed PMID: 28304224.

Articles associés

Ridker PM, Revkin J, Amarenco P, et al. SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. PubMed PMID: 28304242

Ray KK, Landmesser U, Leiter LA, et al. Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol. N Engl J Med. 2017 Mar 17. doi: 10.1056/NEJMoa1615758. PubMed PMID: 28306389

Noel ZR, Beavers CJ. Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Brief Overview. Am J Med. 2017 Feb;130(2):229.e1-229.e4. PubMed PMID: 27751895

Anderson TJ, Gregoire J, Pearson GJ, Barry AR, Couture P, Dawes M, et al. 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. Can J Cardiol. 2016;32(11):1263-82. PubMed PMID: 27712954

Tu JV, Khan AM, Ng K, Chu A. Recent Temporal Changes in Atherosclerotic Cardiovascular Diseases in Ontario: Clinical and Health Systems Impact. Can J Cardiol. 2017;33(3):378-84. PubMed PMID: 28129964.

Autres articles d’intérêt de février-mars 2017

Weitz JI, Lensing AW, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, et al. Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism. N Engl J Med. 2017;376(13):1211-22. PubMed PMID: 28316279.

Kinsinger LS, Anderson C, Kim J, Larson M, Chan SH, King HA, et al. Implementation of Lung Cancer Screening in the Veterans Health Administration. JAMA Intern Med. 2017;177(3):399-406. PubMed PMID: 28135352.

Tsugawa Y, Jena AB, Figueroa JF, Orav EJ, Blumenthal DM, Jha AK. Comparison of Hospital Mortality and Readmission Rates for Medicare Patients Treated by Male vs Female Physicians. JAMA Intern Med. 2017;177(2):206-13. PubMed PMID: 27992617.

van Adrichem RA, Nemeth B, Algra A, le Cessie S, Rosendaal FR, Schipper IB, et al. Thromboprophylaxis after Knee Arthroscopy and Lower-Leg Casting. N Engl J Med. 2017;376(6):515-25. PubMed PMID: 27959702.

Mathieson S, Maher CG, McLachlan AJ, Latimer J, Koes BW, Hancock MJ, et al. Trial of Pregabalin for Acute and Chronic Sciatica. N Engl J Med. 2017;376(12):1111-20. PubMed PMID: 28328324.

Schauer PR, Bhatt DL, Kirwan JP, Wolski K, Aminian A, Brethauer SA, et al. Bariatric Surgery versus Intensive Medical Therapy for Diabetes – 5-Year Outcomes. N Engl J Med. 2017;376(7):641-51. PubMed PMID: 28199805.

Guides de pratique

Mallery LH, Moorhouse P, McLean Veysey P, Allen M, Fleming I. Severely frail elderly patients do not need lipid-lowering drugs. Cleve Clin J Med. 2017;84(2):131-42. PubMed PMID: 28198686.

Gerhard-Herman MD, Gornik HL, Barrett C, Barshes NR, Corriere MA, Drachman DE, et al. 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2017 Mar 21;135(12):e686-e725. PubMed PMID: 27840332

Bennett M, Parkash R, Nery P, Senechal M, Mondesert B, Birnie D, et al. Canadian Cardiovascular Society/Canadian Heart Rhythm Society 2016 Implantable Cardioverter-Defibrillator Guidelines. Can J Cardiol. 2017;33(2):174-88. PubMed PMID: 28034580.

Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. Am J Respir Crit Care Med. 2017;195(5):557-82. PubMed PMID: 28128970.

Référence du quiz clinique

Carrier M, Lazo-Langner A, Shivakumar S, et al; SOME Investigators. Screening for Occult Cancer in Unprovoked Venous Thromboembolism. N Engl J Med. 2015 Aug 20;373(8):697-704. PMID : 26095467