Broadcasting the latest developments in GU cancer Hosted by Brian Rini and Tom Powles Brian Rini MD is Chief of Clinical Trials, Professor of Cancer Research and Professor of Medicine (Hematology/Oncology), Vanderbilt-Ingram Cancer Centre Tom Powles is Director of Barts Cancer Centre, St Bartholomews Hospital and Professor or Genitourinary oncology, Queen Mary University of London
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Episode 392: ASCO GU 2025 - HIF Inhibition with Casdatifan in Refractory RCC
30:09
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30:09Toni Choueiri discusses the updated data from different cohorts of this novel HIF inhibitor.
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Episode 391: ASCO GU 2025 - KIM-1 Data from Checkmate 214
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23:28Vincent Xu discusses this emerging RCC biomarker and data from the Checkmate 214 trial
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Episode 390: ASCO GU 2025 - Pembro-based Doublets in Refractory RCC and COSMIC-313 OS Update
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30:03Laurence Albiges joins the show to discuss novel combos in refractory RCC and an update of the Ipi/Nivo/Cabo COSMIC OS data
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Episode 388: ASCO GU 2025 - FGF3 Inhibition with LOXO-435 in Urothelial Cancer
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25:28Gopa Iyer from MSKCC joins the show to discuss his initial results from this phase 2 trial.
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Episode 387: ASCO GU 2025 -Neoadjuvant Disitamab Vedotin + Toripalimab in HER2+ MIBC: updated efficacy and safety results
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27:07Xinan Sheng. M.D., Professor in the Department of Genitourinary Oncology at Peking University Cancer Hospital &institute in Beijing, China joins us to discuss the update of this trial and impressive pCR rates.
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Episode 389: ASCO GU 2025 - NIAGARA Pathologic CR Updates and Outcomes
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28:23Matt Galsky joins the show to discuss pCR in NIAGARA and clinical implications.
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Episode 386: ASCO GU 2025 - APRI Meta-analysis
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28:58Tanya Dorff from City of Hope joins us to discuss clinical implications of these data and also comment on TALAPRO-2
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Episode 385: ASCO GU 2025 - TALAPRO-2
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32:01Neeraj Aggarwal joins Tom and Brian for an in-depth look at these important data
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Episode 384: ASCO GU Preview
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35:23Silke Gillessen joins Brian and Tom and they discuss what to look forward to in prostate, bladder and RCC at ASCO GU 2025.
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Episode 383: A Neoantigen Vaccine Generates Anti-tumor Immunity in RCC
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33:11David Braun joins the show to discuss his Nature paper on a personalized RCC vaccine
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Episode 382: Uromigos Japan - TROPICs-04の考察
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29:48残念ながらNegative StudyとなったTROPICs-04についてUromigosJapanの3人が忖度なしに、その原因や理由について考察をします!!
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Episode 381: Molecular heterogeneity in urothelial carcinoma and determinants of clinical benefit to PD-L1 blockade
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40:05Romain Banchereau joins the show to discuss and debate this Cancer Cell paper on molecular subtypes in urothelial cancer and implications for checkpoint blockade.
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Episode 380: The Role of SBRT in RCC
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42:02Shankar Siva joins the show to discuss the emerging role of stereotactic body radiotherapy (SBRT) in primary and metastatic RCC tumors.
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Episode 379: Uromigos Japan: 2024年のGU Oncologyを振り返る
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31:313人による2024年のGU oncoloyのレビューを切れ味鋭く解説しています。乞うご期待!
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Episode 378: 2025 Preview of Important GU Data
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41:42Tanya Dorff from City of Hope joins Brian and Tom to review what to expect throughout 2025 and beyond in terms of clinically impactful data in prostate, renal and bladder cancer
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Episode 375: Renal Cancer 2024 Highlights
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43:11David McDermott (and his dog, Finn) join the show to review the top data from 2024 in RCC
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Episode 376: Bladder Cancer 2024 Highlights
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25:37Matt Galsky joins Brian and Tom to discuss the most impactful data in bladder cancer form the past year.
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Episode 377: Prostate Cancer 2024 Highlights
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35:12Silke Gilleson gives Tom and Brian 3 'gifts': Thomas Zilli (Radiation Oncology), Jochen Walz (Urology) and Ken Hermann (Nuclear Medicine) who discuss the 2024 prostate highlights from each of their unique perspectives.
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Episode 374: Mechanisms of HIF Resistance
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34:37Jim Brugarolas joins to discuss his talk from IKCS 2024 and the board topic of resistance to HIF inhibitors.
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Episode 373: KEYNOTE-564 Asian OSとANNARの解説
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34:05JSCO2024で発表されたKEYNOTE-564東アジア人OSデータとANNAR biomarker studyの解説とディスカッションです
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Episode 372: FDA Accelerated Approval Process
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31:30Dan Suzman from FDA joins us to discuss the Accelerated Approval process, requirements, successes and challenges.
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Episode 371: TROPICS-04 Results from ESMO Asia
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33:43Jonathan Rosenberg joins Brian and Tom to discuss this important phase 3 trial and efficacy and toxicity signals.
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Episode 370: Artificial Intelligence in Medical Oncology
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44:46Jacob Kather joins Brian and Tom to discuss emerging AI applications in Oncology
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Episode 369: Paper of the Month with Bishoy Faltas
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45:51Bishoy joins us to discuss his work on extrachromosomal DNA in bladder cancer from his latest Nature publication
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Episode 368: Radiomics in RCC: Live from IKCS
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37:00Andrew Smith from St. Jude's joins us to discuss the emerging field of radiomics and shares his hopes and skepticism
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Episode 367: Abiraterone vs AR inhibitors (Fanta vs Coke) in Prostate Cancer
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56:48Chuck Ryan from MSKCC joins to talk about various aspects of AR inhibition in prostate cancer and relative benefits and risks.
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Episode 366: ARPIs in Prostate Cancer - Are They Different?
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31:51Chris Sweeney and Rob Jones join Brian and Tom to discuss the relative merits of different ARPIs in prostate cancer.
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Episode 365: A Review of the Advanced Prostate Cancer Consensus Conference (APCCC)
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47:59Episode 365: Silke Gillessen and Betrand Tombal join the show to discuss the APCCC meeting and recent publication.
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Episode 364: 腎がんの最新の話題〜IO rechallengeと乳頭型腎がんの治療戦略〜
15:41
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15:41腎がんの最新の話題〜IO rechallengeと乳頭型腎がんの治療戦略〜
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Episode 363: 前立腺がんの最新の話題〜T cell directed therapyとradioligands〜
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14:23前立腺がんの最新の話題〜T cell directed therapyとradioligands〜
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Episode 362: 膀胱がんの最新の話題〜周術期薬物療法とADC〜
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12:42膀胱がんの最新の話題〜周術期薬物療法とADC〜
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Episode 361: The Role of Monotherapy AR Inhibition in Prostate Cancer
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25:43Betrand Tombal joins Brian and Tom to discuss the historic and current data for AR inhibition with monotherapy with AR blockers.
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Episode 360: The SUNRISE Program in Bladder Cancer
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46:19Christopher Cutie from J&J joins the show to discuss the SUNRISE bladder program with the gemcitabine-eluting pretzel across several NMIBC and MIBC states.
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Episode 359: #UromigosLive24 - IO after IO in RCC
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40:41The RCC panel at Uromigos Live 2024 discusses and debates this topic.
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Episode 358: Noticias del Dia 1 de Uromigos Live 2024 en Nashville
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21:59Eneste podcast cubrimos los temas de cáncer urotelial discutidos por los Uromigos. El impacto del estudio NIAGARA en utiliar quimio más inmunoterapia enneadyuvancia de Ca urotelial músculo invasor, el uso de pembrolizumab adyuvante después de los datos del estudio AMBASSADOR y la búsqueda de biomarcadores.…
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Episode 357: #UromigosLive24 - Peri-operative Therapy in Bladder Cancer
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1:03:10Tom leads a panel of Shilpa Gupta, Andrea Apolo, Kala Sridhar and Petros Grivas to discuss and debate this timely topic.
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Episode 356: #UromigosLive24 - Front-line Therapy in Papillary and Non-clear Cell RCC
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26:22Brian moderates the panel that discusses and debates TKI, vs Ipi/Nivo vs IO/TKI
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Episode 355: #UromigosLive24 - Radioligands in prostate cancer
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54:23The Uromigos Live 2024 panel discusses recent radioligand data including PEACE-3
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Episode 354: #UromigosLive24 - T cell directed therapy in prostate cancer
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44:00Brian hosts a panel at Uromigos Live 2024 in Nashville with Michael Morris, Tanya Dorff and Karen Autio
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Episode 353: #UromigosLive24 ADC session
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53:28Tom moderates a live panel of Kala Sridhar, Shilpa Gupta, Andrea Apolo and Petros Grivas on the emerging ADC data in bladder cancer
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Episode 352: ESMO 2024 - RCC and Bladder review
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26:25Tom and Brian finish discussing ESMO 2024 highlights. Even without a guest Tom still interrupts a lot.
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Episode 351: ESMO 2024 review part 1: prostate cancer
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18:48Silke joins us to discuss ESMO 2024 highlights, then the birds start singing....
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Episode 350: ESMO 2024 - NIAGARA
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23:51Fresh of the Presidential session address, Tom discusses his data with Petros commenting.
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Episode 349: ESMO 2024 - Uromigos Japan!!
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30:56Uromigos Japan with Yuji, Hiroshi and Nobu is formed and discuss Hiroshi's ESMO data.
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Episode 348: ESMO 2024 - UpFrontPSMA
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33:52Arun Azad describes this randomised phase II study of sequential 177Lu-PSMA-617 and docetaxel vs. docetaxel in mHSPC
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Episode 347: ESMO 2024 - DV + Pembro in Urothelial Cancer
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17:59Matt Galsky describes his ESMO 2024 abstract of disitimab vedotiin + pembrlizumab in bladder cancer
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Episode 346: ESMO 2024 - PEACE-3: Enza/Radium-223 vs Enza in mCRPC
25:47
25:47
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25:47Silke Gillessen joins us to discuss her Presidential session from ESMO 2024
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Episode 345: ESMO 2024 - SUNNIFORECAST: Ipi/Nivo vs SOC in Non-clear Cell RCC
31:10
31:10
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31:10Lothar Bergmann describes this investigator-initiated trial of Ipi/Nivo vs SOC in Non-clear Cell RCC
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Episode 344: ESMO 2024 - NKT2152, a HIF inhibitor in RCC
22:32
22:32
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22:32Brad McGregor joins Brian and Tom to discuss a new HIF inhibitor, NKT2152, and preliminary data in RCC
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Episode 343: ESMO 2024 - TiNivo-2 Trial
31:23
31:23
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31:23Katy Beckermann discusses the TiNivo-2 study presented at ESMO 2024.
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